My doctor just prescribed me 20mg today after telling her I've tried Zoloft and Lexapro in the past and neither of them worked for me. I'm going to take my first dose tomorrow morning, and I am aware my symptoms of depression and anxiety will get worse along with others, but I'd love hearing positive notes about the med. Prozac has an average rating of 7.2 out of 10 from a total of 1,269 reviews on Drugs.com. 65% of reviewers reported a positive experience, while 20% reported a negative experience. Find patient medical information for Fluoxetine (Prozac, Sarafem, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Consumer ratings and reviews for PROZAC (FLUOXETINE HYDROCHLORIDE). Includes 953 patient ratings with average score of 3.2, comments, side effects, dosage, sex, age, time taken. Read 2282 user reviews of Fluoxetine (Prozac, Sarafem, Others) (Prozac, Prozac Weekly, Sarafem, Selfemra). Average rating: 3.7/5 for effectiveness, ease of use, and satisfaction. Prozac’s ultimate list of PROS and CONS! Please know that every medication could have different effects depending on the individual taking it. Reviews and ratings for Prozac when used in the treatment of depression. 443 reviews submitted. Prozac (fluoxetine) is a depression pill used to treat a wide range of psychological disorders but it is mainly used to treat major depression in adults and children. Our research team analyzes medical studies on Prozac to determine whether or not it's effective against depression. We compare its efficacy to other SSRI drugs like Zoloft, discuss the risk of side effects and share patient reviews including ratings. Considering Prozac? Read real patient reviews covering anxiety, depression, and OCD — including side effects, time to work, and what licensed providers recommend before starting.